The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) carries out basic biomedical research with the aim of understanding the molecular basis of health and disease, and translating these findings as quickly as possible into clinical application. The research involves the diagnosis and treatment of diseases, as well as their prevention.
A master thesis on the topic of "Development of Innovative Technologies in the Area of Protein-Protein Interaction Research” is currently offered in the research group Neuroproteomics and Molecular Mechanisms of Neurodegenerative Diseases headed by Prof. E. Wanker at the Max Delbrück Center for Molecular Medicine in Berlin-Buch.
Our research group specializes in the Identification of protein-protein interactions using high-throughput approaches and in the development of innovative ‘omics’ methods (Trepte et al. J. Mol. Biol. 2015; Arumughan et al. Nat. Commun. 2016).
The focus of the offered thesis project is on the development of a new, mammalian cell-based technology for the detection of protein-protein interactions and its proof-of-concept application to neurodegenerative disease processes, e.g. in Alzheimer’s or Huntington’s disease.
Techniques to be applied in the project comprise widely-used molecular biology and biochemistry methods, mammalian cell culture, CRISPR/Cas9 genome editing and integration of automated liquid handling technologies. The methods to be developed shall be adaptable to high-throughput application and will be based on established techniques. A technology platform for automation is in place.
We are seeking highly motivated, enthusiastic students interested in method development and neurodegenerative disease processes. If you are enrolled in a relevant life science degree program and possess solid theoretical and practical knowledge in biochemistry, molecular and cell biology, please send your application to Dr. Philipp Trepte in the research group Neuroproteomics.
Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Neuroproteomics, Prof. E. Wanker
Dr. Philipp Trepte