We are a young university in the middle of the Ruhr Metropolis.
We are strong in research and teaching, we think in terms of possibilities innstead of limits and develop ideas with a future. We live diversity, promote potential and are committed to educational justice that earned this name.
DFG funded Collaborative Research Center 1430 on ‘Molecular Mechanisms of Cell State Transitions’ at the Center of Medical Biotechnology (ZMB), University of Duisburg-Essen, is seeking for
Doctoral and Postdoctoral
in Molecular and Cell Biology,
Biochemistry, Structural Biology, Computational
Biochemistry, and Tumorbiology
The aim of the collaborative project is to answer fundamental questions about switch-like trigger mechanisms of cell state transitions, from cell cycle progression in cell division to plasticity of cancer cells to achieve an understanding of critical proliferation regulation that will also reveal novel therapeutic strategies for neoplastic diseases. The CRC’s interdisciplinary approach links direct methodological approaches, including in particular sophisticated biochemical reconstitution, as well as single cell and real-time microscopy with new approaches of acute optical and chemical perturbation. The CRC 1430 offers outstanding research opportunities in a multidisciplinary environment with more than 20 highly-renowned researchers from the University of Duisburg-Essen as well as from the Max Planck Institute of Molecular Physiology in Dortmund, the Technical University of Dortmund, the University of Cologne, the University of Muenster and the Goethe University Frankfurt. Positions should be filled by the end of 2021.
For detailed information about the CRC 1430, the individual projects and the application requirements and deadlines, please visit: www.uni-due.de/crc1430 Open doctoral positions
Project A01 – Molecular control of kinetochore microtubule interactions at the metaphase-anaphase transition, Prof. Stefan Westermann/Molecular Genetics
Project A03 – VCP/p97-cofactor complexes at the intersection of DNA repair and checkpoint control, Prof. Hemmo Meyer/Molecular Biology
Project A04 – High-resolution electron microscopy of macro-molecular complexes in cell cycle regulation, Prof. Christos Gatsogiannis/Structural Biochemistry and Cryo- EM
Project A11 – Molecular regulation of differentiation and cell cycle in tumor- repopulating melanoma cells, Prof. Alexander Roesch/Tumor Heterogeneity and Plasticity
Project A12 – Mechanisms of locally controlled histone demethylase activity, Junior Group Leader Simon Poepsel/Structural Biology/Biochemistry
Project A14 – Metastatic transition in pancreatic ductal adenocarcinoma, Emmy Noether Group Leader Dr. Barbara Gruener/Molecular Tumorpathology
Open postdoctoral positions
Postdoc in Hematology, Oncology/Project A09 – Targeting oncogene-induced DNA repair pathway switches with Prof. Christian Reinhardt to molecularly characterize the cell state transition from ordered DSB repair towards HR deficiency in cancer cells
Postdoc in Computational Biochemistry/Project B04 – Hybrid computational strategies for the study of cell states with Prof. Elsa Sanchez-Garcia to deliver molecular insights into Protein-Protein-Interactions relevant for the regulation of cell decisions
Postdoc in Research Data Management/Project INF – RDM – an integrated database and standardised analysis of experimental data with Hemmo Meyer, Stephanie Rehwald and Nina Schulze to develop a well-designed and structured approach to manage, process and share scientific data emanating from the CRC projects
You will tackle questions of the CRC 1430 for which you will find training and support on site. Projects are highly interdisciplinary integrating diverse expertise of faculty in Biology, Medicine, and Chemistry.
We expect applicants to hold (or expect to hold prior to the start of their PhD) an excellent Master degree (or equivalent for PhD positions) or a PhD (for postdoc positions) in Biology, Molecular and Cell Biology, Biochemistry, Chemical Biology, Chemistry, Medicine, or related fields.
We expect you to have proficiency in written and spoken English. Proof of language skills is not necessary, but recommended.
We value passion for science and scientific work as well as independence, curiosity and enthusiasm.
Research experience in an area that is related to the CRC’s scope is essential for successful candidates.
Doctoral and postdoctoral positions starting at the next possible date
Pay grade TV-L 13, temporary employment, 65 % for PhD positions and 100 % for postdoctoral positions
PhD students will have the possibility to actively participate in the integrated Research Training Group on ‘Molecular and Chemical Cell Biology’ within the CRC and profit from the well-structured PhD seminar and the interdisciplinary interaction with other students from the BIOME and CRC-network (see:
http://www.uni-due.de/biome/ or https://www.uni-due.de/crc1430 for details).
Candidates interested in several projects in the CRC1430 are encouraged to apply to multiple laboratories during this recruitment round. Please note that application deadlines, employer, and place of employment may vary! Application documents should include a cover letter with a selection of the project(s) you are interested in, CV, summary of previous Master/PhD/Postdoc projects incl. methods and techniques you have used, certificates and contact details of two referees. Applications and inquiries should be submitted as a single PDF file via email to firstname.lastname@example.org.