Full Professorship (W3) for "Translational Pediatric Glioma Research" (f/m/d)

Full Professorship (W3) for "Translational Pediatric Glioma Research" (f/m/d)

(Ref-No. 2023-0022)

Neuro-oncology represents a central strategic focus of biomedical research and patient care at DKFZ and the Medical Faculty of Heidelberg University. To significantly enhance the cure rate of children suffering from brain tumors, we are looking for an internationally recognized scientist with a background in the field of characterization and modeling of pediatric gliomas and other pediatric brain tumor entities as well as the development of personalized medicine applications. The scientific focus of the professorship will be the application of cutting-edge “omics”- technologies to interrogate the biological underpinnings of pediatric brain tumors. Major goals include identification and functional characterization of driver mutations, resistance mechanisms, characterization of microenvironment-tumor interactions, further development of methylation-based tumor classification, and development of faithful in vivo models. Clinical translation of these findings through the development of molecular diagnostic methods and pre-clinical studies are expected. A central role in the precision oncology program INFORM is strongly desired. The candidate should have outstanding prior work and a broad range of expertise in the areas of next-generation (DNA/RNA sequencing including single-cell sequencing), epigenetic (DNA methylation, ChIPseq) and functional (CRISPR/Cas9) technologies, the biology and genetics of low-grade and high-grade childhood gliomas, the generation of versatile and predictive models, as well as expertise with regard to precision oncology and innovative studies. A strong record of publications and successful third-party funding applications should be documented. The division will be integrated into the existing programs at the Hopp-Kindertumorzentrum Heidelberg (KiTZ), a comprehensive Therapy and Research Center for Pediatric Oncology founded as a joint venture between the DKFZ, the University Hospital and the University Heidelberg. Its objective is to pool research and clinical expertise in an internationally visible center dedicated to pediatric malignancies. The position at the level of a DKFZ Head of Division is endowed with an attractive core funding package including personnel, consumables and investments. In addition, access is given to intramural competitive funding programs. Prerequisites for application are a completed university degree, qualified doctorate and, in accordance with § 47 and § 48 (2) of the Higher Education Law of the state Baden-Württemberg, either a habilitation, a successfully evaluated junior group or a comparable academic qualification. The joint appointment follows the “Jülicher Modell”, where the successful candidate will be appointed as a full and life-time professor at Heidelberg University and granted a leave of absence to the German Cancer Research Center (DKFZ), which will be the employer. Upon fulfillment of the general requirements under civil service law and budgetary law, the appointment to the professorship will normally be made directly on the basis of a lifetime civil servant status (Beamtenverhältnis auf Lebenszeit). Applications should be submitted till February 23, 2023 including curriculum vitae, copies of diplomas and degrees, list of publications, a research concept, and a list with teaching experience to Prof. Dr. med. Dr. h. c. Hans-Georg Kräusslich, Dean of the Heidelberg Medical Faculty, via the application management of the Heidelberg Medical Faculty (https://www.medizinische-fakultaet-hd.uni-heidelberg.de/fakultaet/akademische-laufbahn/berufungen), as well as through the DKFZ online application tool (www.dkfz.de/jobs) to Prof. Dr. med. Dr. h. c. Michael Baumann, Scientific Director and Chair of the Management Board, German Cancer Research Center (DKFZ). We ask for your understanding that application documents submitted by mail will not be returned. The DKFZ and Heidelberg University stand for equal opportunities and diversity. Qualified female scientists are currently underrepresented in leadership positions of DKFZ and are especially encouraged to apply. Candidates with severe disabilities will be given preference if they are equally qualified. Information on the collection of personal data is available at www.dkfz.de/jobs and www.uni-heidelberg.de/en/job-market. Important notice:
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ. Application deadline: February 23, 2023 We offer:

• Interesting, versatile workplace
• International, attractive working environment
• Campus with modern state-of-the-art infrastructure
• Professor remuneration
• Flexible working hours
• Comprehensive further training program