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Post-doctoral researcher (f/m/d) Institute for Genetics
University of Cologne
CRC 1218 I Institute for Genetics
Post-doctoral researcher (f/m/d)
The University of Cologne is one of the largest and most research-intensive universities in
Germany, offering a wide range of subjects. With its six faculties and its interfaculty centres, it
offers a broad spectrum of scientific disciplines and internationally outstanding profile areas,
supported by the administration with its services.
Within the framework of the CRC1218 on "Plasticity of the mitochondrial contact site and cristae
organising complex" (www.sfb1218.uni-koeln.de), our project aims at understanding the tissue
specific composition, architecture and structure of the contact site and cristae organising (MICOS)
complex and the related mitochondrial intermembrane space bridging (MIB) complex.
These multiprotein assemblies are critical to organize the cristae junctions, where the inner
boundary membrane bends towards the mitochondrial matrix, and are thus major players in
controlling mitochondrial morphology often affected in mitochondrial pathologies. Research
of the Brandt lab is cantered around the structural and functional analysis of mitochondrial
multiprotein complexes in health and disease applying a wide range of methodologies (e.g.
Zickermann et al. Science 2015; Guerrero-Castillo et al. Cell Metabolism, 2017; Cabrera-Orefice
et al, Nature Communications, 2018; Researcher ID C-4406-2008)
The postdoctoral researcher will perform a comprehensive structural analysis of the MICOS/
MIB complexes in different tissues, applying our recently developed Complexome Profiling
approach. Implications of variations on cristae morphology and mitochondrial function will
be studied CRISPR/Cas knock-out and mutant cell lines. We further aim at obtaining highresolution
by single particle cryo-electron microscopy. The project will be performed in close
collaboration with other researchers of the CRC1218 and the Brandt group at the Radboud
Institute for Molecular Life Sciences in Nijmegen, Netherlands.
The subject of the doctorate should have been obtained in the field of "Biochemistry" or
"Molecular Life Sciences"
Solid background in molecular biology and experience in cell biology, genetics, or biochemistry
Candidates should have demonstrated outstanding performance through their graduate studies
Besides creativity, a strong ability for problem solving through analytical thinking combined
with an enthusiasm for scientific research is highly desirable
Additionally, we expect good communication skills, fluent English, a high level of independence
and the ability for teamwork
WE OFFER YOU
a multidisciplinary and international environment
a diverse and fair working environment
support in reconciling work and family life
extensive advanced training opportunities
occupational health management offers
local transport ticket at a discount for UoC employees
The position is available from the 01.11.2020 on a full time basis. It is limited to 30.06.2024. If
the applicant meets the relevant wage requirements and personal qualifications, the salary is
based on remuneration group 13 TV-L of the pay scale for the German public sector.
The University of Cologne promotes equal opportunities and diversity in its employment relations.
Women are strongly encouraged to apply and given priority in accordance with the Equal
Opportunities Act of North Rhine-Westphalia (Landesgleichstellungsgesetz – LGG NRW). We
strongly welcome applications from individuals with severe disabilities or people of equivalent
status. Severely disabled applicants of equal merit and qualifications will be given priority.
Please apply online at: https://jobportal.uni-koeln.de with proof of the sought qualifications.
Your application should include a cover letter outlining your motivation and qualifications
for the project, CV, copies of certificates, and letter(s) of reference. The reference number is
Wiss2009-05. The application deadline is 22.09.2020.