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Biologie Molekularbiologie Bioinformatik Humanmedizin Informatik Postdoc Berlin Klinik

  • Scientist / Postdoc (f/m/d) Klinik für Pädiatrie m.S. Onkologie und Hämatologie

    23.03.2022 Charité - Universitätsmedizin Berlin Berlin Scientist / Postdoc (f/m/d) Klinik für Pädiatrie m.S. Onkologie und Hämatologie - Charité - Universitätsmedizin Berlin - Logo
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Scientist / Postdoc (f/m/d) Klinik für Pädiatrie m.S. Onkologie und Hämatologie

Veröffentlicht am
23.03.2022
Bewerbungsfrist
28.03.2022
Vollzeit-Stelle
Charité - Universitätsmedizin Berlin
Berlin
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Working time models – varied and flexible

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Company pension scheme – secured and future oriented

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Corporate season ticket – reduced commute to work

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Health offers – sports, fitness, prevention

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Training and qualification in our own academy

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Employee envelopment – support on your own career path

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A family-friendly employer – certified since 2007

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Internationality and diversity

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Collective agreements – attractive pay with regular increases and binding framework conditions

THE CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN
is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.

SCIENTIST / POSTDOC

CC17 Klinik für Pädiatrie m.S. Onkologie und
Hämatologie

Charité Campus Virchow-Klinikum

Tumor relapses are among the most challenging clinical and fundamental problems in cancer. Current treatment protocols can often achieve complete clinical remission, but tumors still regularly relapse as treatment-resistant disease. Relapses may stem from additional genetic mutations or from switches in the cell phenotype. In some tumor types, tumor cells can adopt a primitive phenotype that is drug-resistant. Such cells may survive treatment and mediate relapses, but their role is enigmatic. Therapies specifically eradicating such primitive cells may prevent the emergence of relapses and improve clinical outcome.
Your area of responsibility:
Neuroblastoma is a childhood tumor of the peripheral sympathetic lineage. Upon therapy, most high-stage neuroblastoma go in complete clinical remission, but the majority ultimately relapses as lethal disease. Recently it was found that neuroblastoma cells can adopt two phenotypes. In vitro, cells can transdifferentiate between a lineage committed- and an immature-phenotype. The immature cells are multi-drug resistant, but it is as yet enigmatic whether they play a role in vivo and are responsible for relapse development in neuroblastoma patients. This project will focus on the role of the immature cell type in relapse development in model systems and the prevalence of these cells in patients. Relapse development will be studied in mouse models of neuroblastoma and explore single cell RNAseq and targeted drugs to define the role of the immature cell type. Bioinformatic analyses play an important role in these studies. Neuroblastoma forms a spearpoint in the research at the Pediatric Oncology Research department of the Charité. This provides a state-of-the-art research environment within the inspiring city of Berlin.
Scientific staff is given sufficient time to carry out their own scientific work in accordance with their employment relationship.
Your profile:
We search a post-doc with a doctoral degree and background in molecular biology and the ambition to realize a strong research line. The project studies a fundamental problem in cancer, but aims to integrate this with a search for clinical approaches that improve the fate of neuroblastoma patients. Initiative and good contactual skills to operate in a multidiciplinary environment are therefore important. The candidate should have experience with molecular analyses and cell culture and an interest in high throughput and bioinformatic analyses. The candidate should be fluent in English and preferably proficient in German.
Applicants with a degree that was not obtained at a German or European higher education institution will have to submit a Statement of Comparability issued by the "Zentralstelle für ausländisches Bildungswesen" (Central Office for Foreign Education – ZAB, https://www.kmk.org/zab/central-office-for-foreign-education/) during the employment process in order to have their education properly acknowledged.

REF. NO.:
DM.70.22b

START:
as soon as possible

LENGTH OF EMPLOYMENT:
31th December 2023

WORKING TIME:
39 hrs. / week

PAY SCALE:
13 according to collective
agreement TVöD/VKA-K
Employees are grouped into pay scales according to their qualifications and personal requirements. You can find our collective bargaining agreements (Tarifverträge) here: www.charite.de/en/careers/

For further information please contact Prof. Rogier Versteeg, e-mail:
rogier.versteeg@charite.de

Applications should preferably be sent by e-mail with a cover letter, curriculum vitae and diplomas as well as job references (each as a PDF / image file) stating the reference number DM.70.22b by 28th March 2022 to the following address:

Charité – Universitätsmedizin Berlin
CVK
Pediatric Oncology and Hematology
Prof. Rogier Versteeg
Augustenburger Platz 1
D-
13353 Berlin

THE CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN
makes its human resources decisions based on suitability, competence and professional performance. At the same time, it strives to increase the percentage of women in management positions and takes this into consideration where candidates are equally qualified within the limits of what is legally possible. Applications from people with a migrant background are also explicitly welcome. Severely disabled applicants are given preferential consideration in the case of candidates with equal qualifications. An extended certificate of conduct must be submitted. Any travel expenses incurred cannot be reimbursed.

Data protection notice: Charité points out that personal data is stored and processed as part of the application process in different areas of Charité (e. g. faculty, staff committee, human resources department). Furthermore, the data may be transferred or processed within the group as well as in locations outside the group (e. g. authorities) to protect legitimate interests. By applying, you agree to our data protection regulations and terms of use, which you can find here.

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