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Postdoc (f/m/x) for the Department of Molecular Toxicology
The UFZ has a strong commitment to diversity and actively supports equal opportunities for all employees regardless of their origin, religion, ideology, disability, age or sexual identity.
We look forward to applications from people who are open-minded and enjoy working in diverse teams.
Place of work:
Leipzig
Working time:
100 %
Contract limitations:
limited contract/2 years
Salary:
Remuneration according to the TVöD public sector up to pay grade 13 including attractive public-sector social security benefits.
Application deadline:
24.03.2024
Your contact for any questions you may have about the job: Dr. Kristin Schubert
Phone: +49 341 6025-1819 ✉ kristin.schubert@ufz.de
Please submit your application via our online portal with your cover letter, CV (please omit your photo, age, or marital status) and relevant attachments.
The Helmholtz Centre for Environmental Research (UFZ) with its 1,100 employees has gained an excellent reputation as an international competence centre for environmental sciences. We are part of the largest scientific organisation in Germany, the Helmholtz Association. Our mission: Our research seeks to find a balance between social development and the long-term protection of our natural resources.
Postdoc (f/m/x)
The job
The Department of Molecular Toxicology seeks a creative and enthusiastic postdoctoral fellow. The position is placed within the Toxicoproteomics group, led by Emmy-Noether-Group leader Kristin Schubert. In this position, the fellow will investigate molecular mechanisms linking chemical exposure to inflammation and adipose tissue dysfunction. The research fellow will use quantitative proteomics approaches to define molecular changes induced in human immune cells and adipocytes by exposure to environmental chemicals of concern at the bulk and single-cell levels. In addition, a strong focus on the role of posttranslational protein modifications is expected, including functional validations using complementary methods. The position requires a solid background in molecular wet-lab techniques and reliable handling of R. The start of the project will preferably be the 1st of June 2024.
Your tasks
Decipher the role of posttranslational protein modifications, like oxidation, phosphorylation and acetylation, in environmental chemical exposed cell culture systems
Advance bioinformatic workflows for the analysis of proteomics/PTMomics data, including deep learning, network propagation or random forest modelling for the identification and prediction of cellular key events and drivers
Establishment and handling of single-cell proteomics workflows using the CellenONE F1.4
Active participation in laboratory group and department meetings, willingness to develop ideas for new research projects, and contribution to grant applications
Carry out collaborative projects with colleagues in partner institutions
We offer
Excellent technical facilities which are without parallel
The freedom you need to bridge the difficult gap between basic research and close to being ready for application
Work in interdisciplinary, multinational teams and excellent links with national and international research networks
A vibrant region with a high quality of life and a wide cultural offering for a balance between family and professional life
Interesting career opportunities and an extensive range of training and further education courses
Your profile
PhD degree (or near completion) in biochemistry, molecular cell biology, immunology or related fields
Experience with mass spectrometry-based proteomics is a plus.
Programming skills with R.
Previous experience in one or more of the following is desired:
Experience in metabolic disruption and/or inflammation cell culture (immune cells and/or adipocytes or organoids
Knockdown/overexpression studies in eukaryotic system
Protein-protein interactions
Excellent communication skills
Ability to organize and prioritize work efficiently
Experience in supervision involving students and/or junior team members
Applications should be written in English
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