The
University Hospital of Würzburg, Medizinische Klinik und Poliklinik II – Chair of Cellular Immunotherapy (Lead: Prof. M. Hudecek), is inviting applications for a
PostDoc position in T cell engineering for treatment of multiple myeloma (m/f/d)
Our research focuses on the development and clinical translation of adoptive immunotherapy of cancer with T cells that have been modified by gene transfer to express chimeric antigen receptors (CARs). Despite impressive results of CD19-directed CAR-T cells for the treatment of B cell leukemia and lymphoma, the development of CAR-T cell therapy for the treatment of other hematologic and solid malignancies is still in its infancy and we are currently conducting preclinical investigations to promote successful clinical translation (Project leads: Priv.-Doz. Dr. Sophia Danhof, Prof. Michael Hudecek).
Your project:
For multiple myeloma, remission durations post CAR-T cell therapy are still limited in most patients. This project is focusing on the identification of resistance mechanisms like immune escape of myeloma cells and insufficient effector function of the cell product and the establishment of strategies to enhance anti-tumor efficacy of CAR-T cells in vitro and in murine models. The long-term goal is the translational exploitability of novel concepts for improved cellular therapy of myeloma. You will be able to explore new concepts in receptor design and gene transfer and make use of novel approaches to improve T cell functionality. You will be able to work on an independent, high-impact project. Work on the project can start immediately on a fixed term position with possibility of extension. Salary is paid according to the German public service scale based on candidates' background and experience (TV-L).
Your qualification:
Applicants for this position should have obtained their master's degree in biomedicine, biology, biochemistry, or a related field with excellent result, and have or be about to complete a PhD thesis in the field of multiple myeloma and/or T cell engineering. They are expected to have expertise in (T cell) immunology, gene engineering, flow cytometry, next-generation sequencing, mouse tumor models and molecular biology. Key characteristics of successful applicants will include a high level of enthusiasm, result-oriented work style, analytical thinking, excellent communication and time management skills and the ability to face scientific challenges with creativity and dedication.
Our team:
Our labs provide a stimulating environment with an international team of experienced, innovative scientists, medical doctors, and technicians with numerous national and international collaborators. Your project is settled within the Mildred-Scheel-Nachwuchszentrum (funded by the German Cancer Aid; chair: Prof. M. Eilers) which provides the framework for intense collaboration and exchange within and outside the research network. The Medizinische Klinik und Poliklinik II at the University Hospital of Würzburg (Chair: Prof. H. Einsele) runs one of the largest bone marrow transplantation and cell therapy programs in Germany providing numerous opportunities for bench to bedside interaction, education, and clinical translation.
We offer:
- Own day-care center with extended opening times (5:30 – 18:00 )
- Attractive payment according to TV-L including company pension scheme and annual special payment
- Work on an independent, high-impact project
- Cutting-edge research in an interantional, well-connected team
Disabled applicants will be considered preferentially in case of equivalent qualifications.
Application:
Please send your application including a letter of motivation (German or English), expected availability date, CV and list of publications, PhD thesis abstract, and an expressive letter of reference or the names of two potential referees as a combined pdf-file by email to:
danhof_s@ukw.de, Reference: “PostDoc Position".
Applications can be submitted until 15.09.2023.
Universitätsklinikum Würzburg
Medizinische Klinik und Poliklinik II – Hämatologie/Onkologie
Priv.-Doz. Dr. Sophia Danhof, MHBA
Versbacher Straße 5, Building E4/R 4.06b
97078 Würzburg
Germany
email:
danhof_s@ukw.de
www.ukw.de
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