University Assistant (prae doc) at the X-ray Structure Analysis Centre
The University of Vienna (20 faculties and centres, 178 fields of study, approx. 9.800 members of staff, about 90.000 students) seeks to fill the position as soon as possible of a
University Assistant (prae doc)
at the X-ray Structure Analysis Centre
Reference number: 10849
Applications are invited for a joint predoctoral assistant position of the
Department of Inorganic Chemistry (head: Prof. Bernhard Keppler) and the Centre for X-ray Structure Analysis (head: Dr. Tim Gruene)
Topic of the PhD project will be the experimental assessment of the oxidation
state of metals in bioinorganic complexes.
Such complexes are central to the development of novel tumour therapeutics. The experimental determination of the oxidation state will lead to the creation of rational synthesis design for
optimal drug uptake and drug delivery to the tumour tissue.
In particular, the PhD project will study on KP-1339, a Ruthenium based anti-cancer drug . The project focusses on the hypothesis ``activation by reduction'' of Ru(III) to
Ru(II) by means of 3D electron crystallography . The PhD candidate will synthesise and crystallise bioinorganic complexes starting from KP-1339 to control its oxidation state. The candidate will collect and analyse electron diffraction data. Samples with well known oxidation state serve for calibration.
The results will be used to rationalise the synthesis of improved anti-cancer drugs that will be inactive during uptake into the body and become activated once the drug has arrived in the tumour tissue. Further, the candidate will develop peptide-based delivery systems for such compounds.
We expect the successful candidate to sign a doctoral thesis agreement within 12-18 months. - Participation in teaching and independent teaching of courses as defined by the collective agreement (excellent command of written and spoken German required) - Supervision of students - Involvement in the organisation of meetings, conferences, symposia - Involvement in the department administration as well as in teaching and research administration.
Master degree in chemistry or equivalent that qualifies to start a PhD position.
Lab experience including Schlenk line and glove box techniques, design and
synthesis of metal-inorganic complexes. Knowledge in crystallography,
preferable documented through course work, experience with crystallographic and
simulation software (e.g. Gaussian, NBO, AOMix, HyperChem), and generally good
Co-authorship for at least one scientific publication with a topic related to metal-inorganic chemistry or crystallography is a plus. English Very good knowledge MUST
The candidate should have good communication skills and should be a good team player. The candidate will be involved in teaching in German. The candidate must be willing to learn German at the beginning of the project. Application documents - Motivation letter (including research interests)- Curriculum vitae - List of publications, evidence of teaching experience (if available) - Degree certificates.
Main research field
Special research fields
Very good knowledge
Very good knowledge
Type of computer skills
Specified computer skills
Applications including a letter of motivation (German or English) should be submitted via the Job Center to the University of Vienna (
http://jobcenter.univie.ac.at) no later than 08.06.2020, mentioning reference number 10849.
For further information please contact Grüne, Tim +43-1-4277-70202.
The University pursues a non-discriminatory employment policy and values equal opportunities, as well as diversity (http://diversity.univie.ac.at/). The University lays special emphasis on increasing the number of women in senior and in academic positions. Given equal qualifications, preference will be given to female applicants.