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Master thesis - Epigenetic Modulation of intracellular degradation in inhibitory GABAergic interneurons
Epigenetic Modulation of intracellular degradation in inhibitory GABAergic interneurons (Master thesis)
in Department of Functional Epigenetics in the Animal Model
Appropriately processing and adapting to incoming stimuli is one of the main functions of mammalian cortical structures. In this context, the fine-tuned equilibrium between excitation and inhibition plays a crucial role which requires a proper development of respective involved cortical cell types.
Although they contribute to 20% of the total neuronal cortical population, GABAergic interneurons control the flow of information in synchronizing the firing patterns of excitatory pyramidal cells by mediating cellular inhibition. Malfunctions in the GABAergic system are documented for a variety of neuropsychiatric disorders, including epilepsy, autism, depression or schizophrenia. In this context epigenetic regulatory processes are assumed to be linked to a proper development and function of cortical interneurons. However, how intracellular processes required for proper cellular homoeostasis like protein degradation are controlled by epigenetic gene regulation remains poorly understood.
Therefore, we attempt to examine the role of epigenetics in exerting control over intracellular degradative pathways in cortical interneurons and the implications for cortical circuit formation and plasticity. Two master projects are offered that will include:
different functional cell culture assays + life cell imaging
siRNA transfection techniques of primary neuronal cell culture
immunocyto- and -histochemistry
molecularbiological methods (plasmid generation, in situ hybridisation, PCR and quPCR)
We are building up a new team at the division of functional epigenetics in the animal model and are looking for interested students joining our team. If interested and wishing more detailed information, please don´t hesitate to contact: