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Ph.D. student position in Cardiovascular Pharmacological Research on Biased GPCR Ligands
Charité University Medicine
Ph.D. student position in Cardiovascular Pharmacological Research on
Biased GPCR Ligands
The Center for Cardiovascular Research, located in central Berlin at the Charité
Campus Mitte, is inviting for applications for a Ph.D.-position, funded by the Else
Kröner-Fresenius Foundation, starting in September 2017. We seek enthusiastic and
highly motivated Ph.D.-students to conduct pharmacological research on biased GPCR
ligands and drug development.
The concept of ligand-biased signaling is based on work by Robert Lefkowitz and Brian
Kobilka (Charité / BIH Visiting Professor 2017 - 2020), which was rewarded with the
Nobel-prize in 2012. Following up on our own previous work on differential G-protein
signaling in vascular disease (Althoff et al, J Exp Med 2012), we now set out to
investigate the still unknown structural basis of ligand-biased signaling and to develop
novel drugs targeting vascular receptors based on this concept. In this respect, we are
integrating a network of leading GPCR researchers.
Work areas will include a high-throughput screening at the Leibniz Institute for
Molecular Pharmacology and various signaling assays, comprising a method transfer
from the INSERM Toulouse (lab of Céline Gales; Sauliere et al. Nat Chem Biol 2012).
Moreover, we will employ a number of murine disease models to test therapeutic
compound effects in vivo. We will further cooperate with structural biologists (Prof.
Hildebrand & PD Dr. Scheerer, Institute for Medical Physics and Biophysics) to define
structure-function relationships using computational modeling and crystallography.
Good skills in molecular cell biology are required. Knowledge in signaling and cloning is
highly appreciated. Candidates should have an excellent command of written and
Salary will be according to German employment rules (E13, 65%), funded by the Else
Kröner-Fresenius Foundation. The contract is offered for three years starting in
Please send your CV with a motivation letter and a reference letter, preferably all in
one PDF, by E-Mail, to:
Till Althoff, M.D., Research Group Leader & Senior Cardiologist
Charité University Medicine Berlin, Department of Cardiology and Vascular Medicine &
Center for Cardiovascular Research; email@example.com
Closing date for applications: July 5, 2017
The Charité University Medicine is an equal opportunities employer